Run up to 30-plex PCR on the instruments you already own.
Signal Chemistry separates amplification from signal generation — enabling broad multiplex panels on existing qPCR and dPCR platforms. Fewer cycles. Cleaner signal. No new hardware.
A new architecture for multiplex PCR.
Three fundamental advantages that change what's possible on your existing instruments.
Get the Complete Picture from One Sample
Up to 30 targets in a single tube, distinguished by amplitude and color mixing. Monitor multiple variants from one sample draw at a fraction of the per-target cost of TaqMan.
Deploy Tomorrow on Your Existing Instruments
Drop-in chemistry for qPCR and dPCR platforms already on your bench. No capital purchase, no retraining, no procurement cycle. Works with FAM and HEX — no new consumables.
Build Broader Panels with Less Development Overhead
Swap primers without redesigning the reporter system. Unlabeled assay-specific material is cheap and fast to iterate. Signal intensity is tunable per target without affecting PCR efficiency.
More targets in one reaction. Simpler than you'd expect.
Standard Amplification
Your primers amplify targets the way they always have. No changes to your upstream workflow or existing protocols.
Universal Signal Generation
A universal processor generates signal in a secondary isothermal reaction — decoupled from the PCR itself.
Amplitude-Based Readout
Read up to 30 targets by amplitude and color on the instrument already on your bench. No cloud software required.
Built for the assays that matter most.
Validated in dPCR across oncology and infectious disease applications.
Monitor the Full KRAS Landscape in One Reaction
A single-tube assay covering all clinically actionable KRAS G12/G13 variants — designed for companion diagnostic workflows where comprehensive coverage and sensitivity define clinical utility.
Detect HPV Even When the Genome Is Fragmented
10-plex assay targeting conserved regions across the HPV16 genome — achieving sub-single-genome sensitivity in a single dPCR reaction. Amplicon size under 90bp.
How far ahead are you with Signal Chemistry?
Multiplex capacity per single tube reaction.
Precision diagnostics shouldn’t require a new instrument.
Signal Bioscience was built with a singular mission: to democratize precision diagnostics. Every advance in multiplexing brings us closer to comprehensive, affordable cancer monitoring — on the instruments already in labs around the world.
Go from concept to working panel in weeks.
We provide services to help assay developers, pharma translational teams, and diagnostics companies build panels faster using Signal Chemistry.
Get Started